Blessed Anna Maria Taigi was born in Siena on May 29, 1769 and baptized the following day. Because of financial difficulties, her parents, Louis Giannetti and Mary Masi, moved to Rome when Anna Maria was six years old.

In the Eternal City, Anna Maria attended the school conducted by the Filippini Sisters for two years. Following her schooling, she worked at various occupations, even that of a maid, to bring financial assistance to her parents.

When still a young girl, she married Dominic Taigi, a pious young man but of difficult and rather coarse character. Disregarding these defects, Anna Maria was more concerned with his virtue, and for the forty-nine years of their married life she conducted herself with the greatest affability and delicacy, finding ample opportunity to exercise continually the virtues of patience and charity.

Their marriage was characterized by the highest Christian principles.
Understanding the profound social and moral values of the Christian marriage and considering it, above all, as one of the highest missions from Heaven, Blessed Anna Maria transformed her home into a real sanctuary in which God had the first place. Docile to her husband in every way, she avoided anything which might irritate him and thus disturb the family peace. Serious and hardworking, she saw to it that nothing was lacking to her family and, in so far as one in her impoverished circumstances could, she was generous to the poor.

She bore seven children, three of whom died in childhood. Two boys and two girls grew to maturity and she provided them with the most accurate and complete religious and secular education.

Having sought to correspond to grace from her childhood, she now began to live a life of intense spirituality. She had one desire only: to love God and to serve Him in everything; she had only one preoccupation: to avoid the least shadow of the slightest voluntary imperfection. She was greatly devoted to the Holy Eucharist, to the Most Holy Trinity, to the Infant Jesus, to the Sacred Passion of Our Lord, and ever had the tenderest devotion to Our Lady.

Anna Maria Taigi is one of the great mystics of the last century. Yet, she achieved her sanctification by living the ordinary life of wife and mother in a spirit of Christian mission and compliance with God's will. Her daily attendance at Mass, her total surrender to God, her readiness to help anyone in need, and her being an active member of the Third Order of the Most Holy Trinity were, at the same time, the sources and the fruits of her intense spiritual life. 

She had a very close friend, Blessed Elizabeth Canori-Mora, who also was a wife and mother. They helped and supported each other in their marriages and difficulties and grew together in holiness and sanctity in their married vocation.

Blessed Anna Maria entered the Third Order of the Most Holy Trinity on December 26, 1808. God enriched her with many supernatural gifts. The most unusual of these was the apparition of a luminous globe like a miniature sun, which shone before her eyes and in which, for forty-seven years, she could see present and future events anywhere in the world as well as the state of grace of individuals, living or dead.